Journal of the American College of Certified Wound Specialists
Volume 1, Issue 3 , Pages 86-91 , July 2009

Impaired Lower Extremity Wound Healing Secondary to Sirolimus After Kidney Transplantation

  • J. George DeVries, DPM

      Affiliations

    • A PGY-2 Resident; Wheaton Fransciscan Healthcare, Milwaukee, WI
    • ,
  • Rachel C. Collier

      Affiliations

    • Podiatry student extern; Wheaton Fransciscan Healthcare, Milwaukee, WI
    • Corresponding Author InformationCorresponding author.
    • ,
  • Jeffrey A. Niezgoda, MD, FACEEP, FACHM

      Affiliations

    • President, Hyperbaric and Wound Care Associates, Milwaukee, WI
    • ,
  • Shawn Sanicola, DPM

      Affiliations

    • Attending Staff, Wheaton Franciscan Healthcare, Milwaukee, WI
    • ,
  • John P. Simanonok, MD

      Affiliations

    • E Staff, Hyperbaric and Wound Care Associates, Milwaukee, WI

References 

  1. Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. J Am Med Assoc. 2005;293:217–228
  2. Lavery LA, Armstrong DG, Vela SA, Quebedeaux TL, Fleischli JG. Practical criteria for screening patients at high risk for diabetic foot ulceration. Arch Int Med. 1998;158:157–162
  3. Armstrong DG, Stacpoole-Shea S, Nguyen H, Harkless LB. Lengthening of the Achilles tendon in diabetic patients who are at high risk for ulceration of the foot. J Bone Joint Surg Am. 1999;81:535–538
  4. Armstrong DG, Lavery LA, Harkless LB. Validation of a diabetic wound classification system. Diabetes Care. 1998;21:855–859
  5. Banks AS, Downey MS, Martin DE, Miller SJ. McGlamry's Comprehensive Textbook of Foot and Ankle Surgery. 3rd ed.. Philadelphia, PA: Lippincott, Williams, & Wilkins; 2001;
  6. Schaffer M, Schier R, Napirei M, Michalski S, Traska T, Viebahn R. Sirolimus impairs wound healing. Langenbecks Arch Surg. 2007;392:297–303
  7. Fife C, Buyukcakir C, Otto G, et al. The predictive value of transcutaneous oxygen tension measurement in diabetic lower extremity ulcers treated with hyperbaric oxygen therapy: a retrospective analysis of 1144 patients. Wound Repair and Regeneration. 2002;10(4):198–207
  8. Mehrabi A, Fonouni H, Kashfi A, et al. The role and value of sirolimus administration in kidney and liver transplantation. Clin Transplant. 2006;20(suppl. 17):30–43
  9. Physicians' Desk Reference. 61st ed.. Montvale, NJ: Thomson PDR; 2007;
  10. Kahan BD. Sirolimus-based immunosuppression: present state of the art. J Nephrology. 2004;17(suppl 8):32–39
  11. Dean PG, Lund WJ, Larson TS, et al. Wound-healing complications after kidney transplantation: a prospective, randomized comparison of sirolimus and tacrolimus. Transplantation. 2004;77:1555–1561
  12. Flechner SM, Zhou L, Derweesh I, et al. The impact of sirolimus, mycophenolate mofetil, cyclosporine, azathioprine, and steroids on the wound healing in 513 kidney-transplant recipients. Transplantation. 2003;76:1729–1734
  13. Guilbeau JM. Delayed wound healing with sirolimus after liver transplant. Ann Pharmacotherapy. 2002;36:1391–1394
  14. Kuppahally S, Al-Khaldi A, Weisshaa D, et al. Wound healing complications with de novo sirolimus versus mycophenolate mofetil-based regimen in cardiace transplant recipients. Am J Transplant. 2006;6:986–992
  15. Mehrabi A, Fonouni H, Wents M, et al. Wound complications following kidney and liver transplantation. Clin Transplant. 2006;20(suppl 17):97–110
  16. Valente JF, Hricik D, Weigel K, et al. Comparison of sirolimus vs mycophenolate mofetil on surgical complications and wound healing in adult kidney transplantation. Am J Transplant. 2003;3:1128–1134
  17. Zakliczynski M, Nozynski J, Kocher A, et al. Surgical wound-healing complications in heart transplant recipients treated with rapamycin. Wound Repair Regen. 2007;15:316–321
  18. Brewer JD, Otley CC, Christenson LJ, Phillips PK, Roenigk RK, Weaver AL. The effects of sirolimus on wound healing in dermatologic surgery. Dermatol Surg. 2007;34:216–223
  19. Andros G, Armstrong DG, Attinger CE, et al. Consensus statement on negative pressure wound therapy (V.A.C. therapy) for the management of diabetic foot wounds. Ostomy Wound Manage. 2006;Jun(suppl 1):32
  20. Niezgoda JA. Combining negative pressure wound therapy with other wound management modalities. Ostomy Wound Manage. 2005;51(2A suppl):36S–38S
  21. Tibbles PM, Edelsberg JS. Hyperbaric-oxygen therapy. NEJM. 1996;334(25):1642–1648

PII: S1876-4983(09)00086-1

doi: 10.1016/j.jcws.2009.06.001

Journal of the American College of Certified Wound Specialists
Volume 1, Issue 3 , Pages 86-91 , July 2009

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